Propylene oxide is a colorless, lowboiling and highly volatile liquid with a sweet ether propylene oxide reacts readily with alcohols, amines, and acids. Read the product manufacturers material safety data. The information in cameo chemicals comes from a variety of data sources. The chemical identifier fields include common identification numbers, the nfpa diamond u. Propylene oxide handling and storage considerations tech. In the case of propylene oxide or ethylene oxidepropylene oxide mixtures, all cargo transfer lines, spool pieces and jump lines are subject to the same restriction for prior products as are cargo tanks. Consumers may be exposed through ingestion of propylene oxide residues in foods resulting from its use as an indirect food additive or by contact with. Cover with absorbent sheets, spillcontrol pads or pillows. Department of transportation hazard labels, and a general description of the chemical. This relatively low ld 50 indicates that propylene imine is a poisonous material and extreme care should be used to avoid ingestion.
Propylene oxide also reacts with water to form back to top product uses12, propylene oxide is an intermediate used in the manufacture of a wide variety of important chemical products such as. Box 4980 the woodlands, tx 77387 telephone numbers transportationemergency chemtrec. Identification of the substancemixture and of the companyundertaking 1. Physical and surface active properties of ethoxylates are altered by the inclusion of propylene oxide po groups. Propylene oxide and propylene oxide monitoring interscan. Move containers from fire area if this can be done without risk. P4648 410 this document is only controlled while on the praxair, inc. No action shall be taken involving any personal risk or without suitable training.
Propylene oxide is also used as a reactant to produce alkanol amines from ammonia or amines and as an intermediate in the production of allyl alcohol. Firefighting measures promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. Empty containers pose a fire risk, evaporate the residue under a fume hood. Guidelines for validation of propylene oxide pasteurization. Reacts with grignard reagents and organolithium compounds. Lyondellbasell is the worlds leading producer of propylene oxide po, a commodity chemical used in the manufacturing of thousands of everyday products, ranging from antifreeze to cosmetics. Propylene epoxidation using molecular oxygen is a promising, alternative route to synthesize propylene oxide po, a chemical of great industrial importance 1 2345. Instability and reactivity hazards propylene oxide is a stable material that will not decompose under normal conditions of temperature and pressure. Only properly trained personnel should handle propylene oxide. Studyhazard statement category 1 category 2 category 3 category 4 category 5. Page 18 safety data sheet according to 19072006ec, article 31 printing date 07. Cdc niosh pocket guide to chemical hazards propylene oxide. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Be careful that the product is not present at a concentration level above tlv. Uses advised against food, drug, pesticide or biocidal. An explosion occurred when propylene oxide was added to an epoxy resin. The ld 50 of propylene imine on oral ingestion of a single dose by rats is 19 mgkg. From our library of articles, sigmaaldrich presents gc analysis of propylene oxide enantiomers on astec chiraldex ata keywords. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. It is also used as a pesticide and a fumigant for the sterilization of packaged foods and plastic medical instruments.
Methyloxirane, 12 epoxypropane, methyl ethylene oxide, propylene epoxide. Propylene dichloride 1,2dichloropropane 78875 hazard summary propylene dichloride is used as a chemical intermediate in several industries. Prolonged exposure to vapor of even low concentrations can result in nausea and vomiting. Do not use this product without fully reading and understanding the label and the current material safety data sheet. Repeated exposure can result in significant skin absorption. Acute shortterm exposure of humans and animals to propylene oxide has caused eye and respiratory tract irritation. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Propylene oxide 75569 hazard summary propylene oxide is used in the production of polyethers the primary component of polyurethane foams and propylene glycol. Dimethylsiloxanevinylmethylsiloxane propylene oxideethylene oxide block copolymer safety data sheet 02192015 en english us sds id. Propylene oxide is an organic compound with the molecular formula ch 3 chch 2 o. Page psm01p010 47 skc propylene oxide dig holding area such as lagoon, pond or pit for containment. Propylene glycols consume another 20% of the total, and propylene glycol ethers consume about 5%. Propylene oxide propylene glycols sector group guidelines for handling and distribution of propylene glycol uspep revision 2 march 2009 3 contents 1 introduction 5 1.
Nonionic surfactants containing propylene oxide springerlink. Pdf direct oxidation of propylene to propylene oxide. The optimum position of the po was shown to be a single discrete block of po located in approximately the middle of the ethoxylate chain. Use only nonsparking tools and equipment in the cleanup process. It is a chiral epoxide, although it is commonly used as a racemic mixture. Ventilation equipment should be explosionresistant if explosive concentrations of material are present. Polyether polyols consume the largest share of propylene oxide using between 6070% of the total global volume. Handling and storage advice on general occupational hygiene conditions for safe storage, including any incompatibilities eating, drinking and smoking should be prohibited in areas where this material is. Propylene oxide reacts with water to produce propylene glycol 57556, dipropylene glycol, tripropylene glycol, and higher molecular weight polyglycols. Contain and absorb spilled liquid with noncombustible, inert absorbent material e. Find msds or sds, a coa, data sheets and more information.
It was concluded that polymerization was catalyzed by an amine accelerator in the resin bretherick, 5th ed. Its major application is its use for the production of polyether polyols for use in making polyurethane plastics. It can be used in the synthesis of ligands to prepare of pbii based coordination nets for the fabrication of white lightemitting diode materials. Propylene oxide is used primarily as a chemical intermediate in the production of polyethers and propylene glycol. Acute shortterm inhalation exposure to high levels of propylene dichloride by humans results in effects on the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Health science park 3154 caroline drive haw river, nc 27258 usa information telephone number.
This colourless volatile liquid with an odour resembling ether, is produced on a large scale industrially. Identification product name propylene glycol cat no. High concentrations may produce irritation of the eyes, lungs, and mucous membranes. The location of po within the ethoxylate eo chain can be as important a factor as the relative amounts of po and eo. Product data and technical information corporate statement.
This material does not contain any class 1 ozone depletors. Methyl glycol uspfcc recommended use laboratory chemicals. Propylene oxide splashed in the eye can cause severe burning, tearing, redness, swelling and corneal burns, propylene oxide vapors also can cause. Propylene oxide is a chemical intermediate used to make a wide range of. No hazardous decomposition products known at room temperature. Safety data sheet propylene tetramer date prepared. Completely read this guide prior to handling containers. Gc analysis of propylene oxide enantiomers on astec chiraldex ata. Chromatography, flame ionization detector, gas chromatography, purification, separation. Propylene oxide is a synthetic, highlyflammable, volatile, colorless liquid that is soluble in water and miscible with many organic solvents. Msds30390072005e 11 toxicological information oral toxicity. Dermal contact, even with dilute solutions, has caused skin. Symptoms may include dizziness, headache, nausea and loss of coordination. Safety data sheet creation date 19nov2009 revision date 19mar2019 revision number 7 1.
Collect with absorbent into suitable container water release. Propylene oxide undergoes ringopening upon treating with nucleophiles such as grignard reagents or organolithium compounds to yield corresponding secondary alcohols. Propylene oxide reacts with water to produce propylene glycol 57556, dipropylene glycol, tripropylene. Guidelines for validation of propylene oxide pasteurization overview propylene oxide ppo is a registered fumigant in the us for reduction of bacteria, yeasts, and mold on raw nut meats, etc. Propylene oxide in liquid or solid solution form may be absorbed through the skin and produce toxic effects.
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